Strategies for Access to Kidney Transplantation for Highly Sensitized and Incompatible Patients
نویسندگان
چکیده
One of the major challenges in developing programs for kidney transplantation is represented by presence antibodies targeting HLA donor recipients and, particular cases, incompatibility ABO blood groups among and recipient living donors [...]
منابع مشابه
ABO blood type-incompatible kidney transplantation and access to organs.
OBJECTIVE To determine whether ABO-incompatible (ABOi) kidney transplantation can be performed safely and result in acceptable posttransplantation outcomes. DESIGN Prospective study. SETTING Transplantation center. PATIENTS In the 1½ years of a new program, 18 patients with renal failure and an ABOi living kidney donor were included in the study. All donors and recipients were of i...
متن کاملABO-Incompatible Kidney Transplantation: Overview and New Strategies
The increasing shortage of human organs for transplantation has regained interest in blood group ABO-incompatible kidney transplantation, especially living donor kidney transplantation. After being performed at a few centers during the 1980s, ABO-incompatible renal transplantation has continued to expand over the years. More than 1000 ABO-incompatible living donor transplantations have been per...
متن کاملABO-Incompatible Kidney Transplantation
ABO antigens are composed of sugar chains and exist not only on red cells but also on many other cells including endothelial cells and epithelial cells of various organs such as kidney, heart, bowel, lung, and pancreas (Marionneau et al., 2001). ABO antibodies, which have been called as isoagglutinins, are preformed antibodies directed against missing A or B antigens. The source of anti-A/B ant...
متن کاملABO-Incompatible Kidney Transplantation
ABO-incompatible (ABOi) kidney transplantation has long been considered a contraindication to successful kidney transplantation. During the last 25 years, increasing organ shortage enforced the development of strategies to overcome the ABO antibody barrier. In the meantime, ABOi kidney transplantation has become a routine procedure with death-censored graft survival rates comparable to the rate...
متن کاملAnti-HLA antibody repertoire after IVIg infusion in highly sensitized patients waiting for kidney transplantation.
Polyclonal intravenous immunoglobulin (IVIg) treatment reduces crossmatch positivity and increases rates of transplantation in highly sensitised patients (HS). We quantified the panel reactive antibody (PRA) by microlymphocytotoxicity (MLCC), and we analysed anti-HLA class I and class II IgG specific antibody repertoire by Luminex before and after IVIg infusion alone in HS patients awaiting kid...
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ژورنال
عنوان ژورنال: Transplantology
سال: 2023
ISSN: ['2673-3943']
DOI: https://doi.org/10.3390/transplantology4020009